comX [2017-03-21 16:18:21]

competence pheromone precursor, transfers cell density signal to ComP; triggers the production of surfactin

locus: BSU31700

pI: 4.00

mw: 6.00 kDa

protein length: 55 aa

gene length: 165 bp

function: quorum sensing

product: competence pheromone precursor

essential: no

synonyms

Genomic Context

categories

• [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
• [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
• [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]

Gene

Coordinates: 3,255,853 -> 3,256,020

Phenotypes of a mutant

• the mutation suppresses the mucoid phenotype of ''[gene|86C729C7D5ABEE519ADC4A893940600BBB655EF1|motA]'' or ''[gene|FE56753D061344B0F10A6523F49C5C7356AA40B6|motB]'' mutants due to loss of [protein|D343D2096664A972026D911E7A17A35C7B1CD1C9|DegU] phosphorylation and concomitant reduced expression of the ''[gene|86C05126ADBA22BB1771B1FA3D214B2E7A36311E|capB]-[gene|D66994D077D1382B88FF65075E44C2A31089548F|capC]-[gene|A696434A086A428D411CAF45B37CD8F82AC2503F|capA]-[gene|6B61DCE8D27776EBF942621D3AE90F410FD13F37|capE]'' operon [Pubmed|24296669]

The protein

Modification

• is synthesized as an inactive precursor, cleaved, and modified (prenylated) by [protein|FDACEF9DDC3BEA4EB013AE67BC47ADA532F00205|ComQ] prior to excretion [Pubmed|22878193]

[SW|Localization]

• secreted (according to Swiss-Prot)

Expression and Regulation: [[this]]

References

Reviews

• 22024380

Original publications

• 16407988,11133937,12067344,19202088,14679219,15564679,17240141,19605685,1715859,22878193,24296669,22511326,21636272,24425772,24788106,25757097,26276536,26787913,26927849